Artex 50mg Tablet-12pcs Box

✔️ Uses of Artex 50mg Tablet

• Malaria

✔️ Side Effects of Artex 50mg Tablet

• Dizziness
• Headache
• Stomach pain
• Diarrhea
• Injection site pain
• Fever with body pain
• Anemia
• Low WBC and Platelet count
• Chills or shivering
• Dark or Clay colored stools
• Rapid weight gain

✔️ How does Artex 50mg Tablet work?

Artex 50mg Tablet works by inhibiting protein synthesis in the final stage of the malaria cycle conversion in humans. Thus destroys the parasite and prevents the recurrence of the disease.

✔️ Quick Suggestions:

• Artex 50mg Tablet should be taken with food or drinks enriched with fat such as milk.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• It may cause dizziness and sleepiness. Use caution while driving or doing anything that requires concentration.
• Do not take this medicine if you are in the first 3 months of pregnancy. Inform your doctor if you are breastfeeding.
• Inform your doctor if you notice flu-like symptoms such as chills, fever, muscle pains, and any changes in a heartbeat.
• You may be asked for a regular blood test once a week while taking this medicine.

✔️ Indications:

Arinet, an artemisinin derivative, is a potent antimalarial drug indicated for the following conditions:

1. Treatment of severe and complicated malaria caused by Plasmodium falciparum in both adults and children.
2. Treatment of uncomplicated malaria in areas with multidrug-resistant Plasmodium falciparum.
3. Suitable for salvaging patients with pernicious malaria and treating malaria caused by Plasmodium falciparum and Plasmodium vivax.

✔️ Pharmacology

Artesunate, the active component, is metabolized to the active DHA. It generates free radicals inhibiting protein and nucleic acid synthesis in Plasmodium parasites during all erythrocytic stages. It may also lead to alkylation of parasitic proteins.

✔️ Dosage & Administration:

Artesunate 50 mg tablet:

• Adults: Two tablets twice on the first day, followed by one tablet twice daily for the next four days (4, 2, 2, 2, 2).
• Children:
  • 1-3 years: 3 tablets for 5 days (1, 1⁄2, 1⁄2, 1⁄2, 1⁄2)
  • 4-5 years: 6 tablets for 5 days (2, 1, 1, 1, 1)
  • 6-12 years: 8 tablets for 5 days (3, 2, 1, 1, 1)

Artesunate 100 mg tablet:

• Adults: One tablet twice on the first day, followed by half a tablet twice daily for the next four days (2, 1, 1, 1, 1).
• Children:
  • 4-5 years: 3 tablets for 5 days (1, 1⁄2, 1⁄2, 1⁄2, 1⁄2)
  • 6-12 years: 4 tablets for 5 days (1 1⁄2, 1, 1⁄2, 1⁄2, 1⁄2)
  • Patients aged over 12 years: Same as adult dose.

Dosage for Malaria Prevention: Two Artesunate 50 tablets (or one Artesunate 100 tablet) as a single dose once a week, from one week before entering a malaria-affected area to four weeks after leaving.

✔️ Interaction

• Interaction with other artemisinin drugs (e.g., artemether, arteether) prolongs PQ and QT interval.
• Interaction with antimalarial drugs (e.g., quinine, quinidine, mefloquine, halofantrine) with cardiac action.
• Interaction with drugs prolonging QT interval (e.g., erythromycin, terfenadine, astemizole, probucol, procainamide, disopyramide, amiodarone, bretylium, bepridil, sotalol, tricyclic antidepressants, and neuroleptics).

✔️ Contraindications

Artesunate is contraindicated in patients with known hypersensitivity to Artemisinin and its derivatives or inactive ingredients.

✔️ Pregnancy & Lactation

Considered safe for treating malaria in pregnancy, but further study is needed. Use with caution during breastfeeding, and it's recommended to stop breastfeeding during treatment.

✔️ Precautions & Warnings

• Caution in severe vomiting patients.
• Intravenous or intramuscular injection is preferred for emergency severe malaria treatment.
• Use under the advice of a Registered Physician.
• Do not exceed the recommended dose.

✔️ Storage Conditions

Keep below 30°C, away from light and moisture. Keep out of reach of children.